RANDOX Barbiturates ELISA

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Introduction:

Barbiturates are a class of around 12 compounds derived from barbituric acid. They are central nervous system depressants that can be used as sedatives, hypnotics, anaesthetics or anti-epileptic drugs. Barbiturates can be divided into three main groups according to their duration of action. The ultrashort-acting barbiturates are used clinically as anaesthetics whilst the long-acting barbiturates have anti-convulsing properties. Short-acting compounds can be used as hypnotics and favoured by drug abusers due to their ability to reduce tension and produce a feeling of tranquillity. An overdose of barbiturates can lead to a dramatic fall in blood pressure and body temperature, depressed respiration or coma.

Cross Reactivity

Analyte Compound
Cross Reactivity %
Barbiturates
LOD: 17.3 ng/mL
Phenobarbital 100
Secobarbital
184.7
Cyclopentobarbital
132.8
 
Amobarbital
109.9
 
Butabarbital
77.5
 
Pentobarbital
76.5
 
Butalbital
32.1
 
Barbital
20.5
 
Hexobarbital
<1