RANDOX Methamphetamine EILISA

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Introduction:

Methamphetamine is a Central Nervous System (CNS) stimulant that causes hypertension and tachycardia with feelings of increased confidence, sociability and energy. Acute intoxication causes serious cardiovascular disturbances as well as behavioural problems. Methamphetamine is metabolized in the liver by aromatic hydroxylation, N-dealkylation, and deamination; at least 7 metabolites have been identified in urine. The half-life of methamphetamine is 4 to 5 hours. Following oral administration of methamphetamine hydrochloride, approximately 62% of the administered dose is excreted in urine within the first 24 hours, with metabolites and unchanged drug accounting for about two-thirds and one-third, respectively, of the recovered drug.

Cross Reactivity

Analyte Compound
Cross Reactivity %
'Benzo Fury' 5-MAPB HCI 146.5
5-MAPDB HCI
41.8
6-APB HCI
1.1
 
5-APB HCI
<1
 
5-APDB HCI
<1
 
5-IT
<1
Cathinone/Bath Salts Methylone HCI <1
R(+)Methcathinone HCO
<1
S(-)Fluoromethcathinone HCI
<1
 
3-Fluoromethcathinone HCI
<1
 
Methylethcathinone
<1
 
N-Ethylcathinone HCI
<1
 
Ethylone HCI
<1
 
Buphedrone HCI
<1
 
MDPBP HCI
<1
 
MDPV HCI
<1
 
Naphyrone HCI
<1
 
MDPPP HCI
<1
 
Cathinone
<1
 
Butylone
<1
 
Flephedrone HCI
<1
 
Methedrone
<1
Designed Amphetamine Analogues DOB <1
DOM
<1
DOET
<1
 
TMA
<1
 
2C-E
<1
 
2C-B
<1
 
2C-1
<1
Methamphetamine
LOD: 0 ng/mL
(+)-Methamphetamine 100
PMMA HCI
157.5
S(+)-Methamphetamine
83.9
 
MDMA
83.7
 
(±)-Methamphetamine
40.4
 
MDEA
2.8
 
BDB
1.1
 
d-Amphetamine
<1
 
I-Amphetamine
<1
 
(±)-Amphetamne
<1
 
S(+)-Amphetamine
<1
 
R(-)-Amphetamine
<1
 
R(-)-Methamphetamine
<1
 
I-Methamphetamine HCI
<1
 
(±) -MDA
<1
 
(±)-MBDB HCI
<1
 
Phentermine
<1
 
TFMPP
<1
 
PMA HCI
<1
 
(1S,2S)-(+)-Pseudoephedrine
0.2
 
Methylphenidate
<1
 
Ephedrine
<1