RANDOX TCAs (Tricyclic Antidepressants) ELISA

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Introduction:

Tricyclic antidepressants (TCAs) are a group of drugs that contain a characteristic three ringed nucleus structure. TCAs work by inhibiting the reuptake of serotonin and norepinephrine back into brain cells and are rapidly absorbed and have a long half-life. TCAs drugs include Amitriptyline, Amoxapine, Desipramine, Doxepin, Imipramine, Nortriptyline, Proptriptyline and Trimipramine. They have been used in the treatment of various forms of depression, anxiety disorders, attention deficit hyperactivity disorder and enuresis in children. TCA antidepressant drugs are among the most toxic and commonly encountered causes of self-poisoning compared to other types of antidepressants.

Cross Reactivity

Analyte Compound
Cross Reactivity %
TCAs (Tricyclic Antidepressants)
LOD: 10.9 ng/mL
Nortriptyline 100
Imipramine N-oxide
1127
N-desmethyl Trimipramine
396.5
 
Imipramine
294
 
Trimipramine
238
 
Desipramine
206
 
Cyclobenzaprine
201
 
Amitriptyline
190
 
Opipramol
167
 
Promazine
117
 
Maprotiline
96
 
Doxepine
95
 
Clomipramine
76
 
Protriptyline
67
 
Northiaden (Nordothiepin)
63.2
 
Cyproheptadine
61
 
Lofepramine
58
 
Dothiepin
50
 
Chlorpromazine
24.3
 
Norclomipramine HCI
22.1
 
2-Hydroxy imipramine
19.5
 
Nordoxepin
19.4
 
Perphenazine
17.3
 
Prochlorperazine
9.3
 
10-OH amitriptyline
6.4
 
2-OH desipramine
5.1
 
Quetiapine Fumarate
4.5
 
Thioridazine HCI
0.5
 
Carbamazepine
0.3
 
Cetirizine diHCI
0.3
 
Orphenadrine HCI
0.2
 
Amoxapine
0.1
 
Hydroxyzine diHCI
<0.1
 
Oxcarbazepine
<0.1
 
Diphenhydramine HCI
<0.1
 
Carbam,azepine 10,11 epoxide
<0.1
 
10-Hydroxynortriptyline
<0.1
 
Iminostilbene
<0.1
 
Mianserin
<0.1