RANDOX Benzodiazepines ELISA

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Introduction:

Benzodiazepines are a group of structurally related central nervous system depressant drugs that are widely prescribed due to their range of uses. Benzodiazepines act as a sedative and slow down the bodily functions. This reduces brain activity in the areas of the brain responsible for rational thought, memory, emotions and essential functions such as breathing. Benzodiazepines have the potential to be abused both in high doses and in low therapeutic doses. Chronic abuse leads to blurred vision, confusion, slow reflexes, slurred speech and hypotension. Overdose and death are usually the result of the combination of benzodiazepines with other drugs or alcohol.

 

Cross Reactivity

Analyte Compound
Cross Reactivity %
Benzodiazepines
LOD: 6.62 ng/mL
Diazepam 100
Alprazolam
252.2
Nordiazepam
187.1
 
Estazolam
128.7
 
Midazolam
109.2
 
Oxazepam Glucuronide
100.5
 
Bromazepam
97.1
 
Oxazepam
90.8
 
Clobazam
75.1
 
Temazepam
69.1
 
Alpha-OH-Alprazolam
51.7
 
Nitazepam
49.7
 
N-Desmethylflunitrazepam
35.2
 
Phenazepam
34.8
 
Temazepam Glucuronide
29.2
 
Triazolam
26.8
 
Lorazepam
25.7
 
Lorazepam Glucuronide
15.5
 
Flunitrazepam
11.8
 
Clonazepam
6.4
 
Lormetazepam
5.7
 
Prazepam
1.0
 
Chlordiazepoxide
<1
 
Flurazepam
<1
 
7-Aminoclonazepam
<1
 
7-Aminoflunitrazepam
<1
 
7-Aminonitrazepam
<1
 
Etizolam
<1