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SP Cellthru BigBead Plus

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EQUL-BSM28 SP Cellthru BigBead Plus EA call for price none
Introduction:
Product Code11024
Bead Size300-500µm
Matrix Structure4% agarose, hardened
Flow rate5000cm/h*
Binding Capacity50mg BSA/ml resin
Cleaning0.5M NaOH
Storage Conditions20% ethanol, 2-8C
Temperature stability range2°-121°C
Functional ligand-SO3
Ion Exchanger TypeStrong cation
pH stability range2-14
Coupling conditionsDependent on target functional group
Chemical stabilityCommon aqueous, organic, high salt, denaturants
Physical stabilityNegligible volumbe changes due to pH or Ionic state
Drug master fileU.S. Food & Drug Administration

*Flow rate determined in a 1.5x5cm column



- Large particle diameter allows crude material to pass through the column with little to no backpressure during direct capture
- Highly robust, chemically stable beads are ideal for process-scale separations
- High product recovery, up to 95%
-cGMP manufacturing; Regulatory Support File available
-DMF with USFDA

SP Cellthru BigBead Plus is a large particle, strong cation exchanger. The strong ion exchange beads stay charged and maintain high capacities over a wide working pH range. In weak ion exchangers, capacity is a function of pH.

Ion exchange Cellthru BigBead Plus resins are made of a hardened agarose matrix with ion exchange groups attached through a spacer arm. Hardening increases the chemical and mechanical stability of the matrix.

Cellthru BigBeads are used for viscous feed streams and direct capture in standard packed-bed applications using specially manufactured columns. Scale up from pilot to production scale follows a linear relationship, reducing the time spent on method development.