Protein A Ultraflow

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EQUL-BSM14 Protein A Ultraflow EA call for price none
Product Code37656
Bead Size40-160um
Agarose concentration4%
Flow rate1500cm/h*
Binding capacity50mg h-lgG/ml gel(static); 40mg h-lgG/ml gel (dynamic)**
Cleaning6M guanidine, pH 10; 50% methanol, 0.5M NaOH, 15min; 0.1 NaOH 30min - 1hr
Storage conditions20% ethanol, 2-8C
Temperature stability rangeAmbient
Functional ligandRecombinant Protein A
LeachingLess then 15ng/mg
pH stability range2-10
Chemical stability8M urea, 6M guanidine, ethanol and common buffers
Drug master fileU.S. Food & Drug Administration

*Flow rate determined in a 1.5x5cm column
**Dynamic binding capacity determind on a 1.5x13cm column

-High dynamic binding capacity
-High flow rate
-Cleanable with 15min 0.5M NaOH washes for up to 50 runs (retaining 80% binding efficiency) Immobilized on Sterogene's patented Ultraflow 4 matrix
-Industrial process-ready
-No animal-sourced materials are used in the manufacturing of either raw materials or the finished product
-Protein A Cellthru plus also available
-cGMP manufacturing; Regulatory Support File available

Protein A is a cell wall protein derived from Staphyloccal aureus that has the ability to bind the Fc region of lgG molecules. Protein A Ultraflow consists of recombinant protein A immobilized to the base matrix (a highly cross-linked 4% agarose), forming a stable thioether linkage that results in excellent gel stability, low ligand leaching, and a high binding capacity for lgG.

Sterogene's Protein A Ultraflow is comparable to some of the highest quality agarose-based recombinant Protein A resins on the market today. And with its high subsistution levels, great flow rates and low leaching, it makes an excellent choice for a new process, or to update your existing Protein A process.