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Epoxy Activated Ultraflow 4

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Introduction:
Product Code2710
Bead Size40-160um
Agarose concentration4%
Molecular exclusion limit4 million Daitons
Spacer arm12 atoms, hydrophilic
Flow rate4000cm/h*
Functional group to attachThiol, amino, or hydroxyl groups (pH dependent)
Functional ligandExpoxy
Coupling in organic solventsYes
Coupling in a packed columnNo
Coupling conditionsDependent on target functional group
Drug master fileU.S. Food & Drug Administration

*Flow rate determined in a 1.5x5cm column



-For immobilizing peptides and small proteins through thiol, amino or hydroxyl
-Multiple immobilization functionality allows more then one type of ligand immobilization
-High flow rates
-High subsititution levels: immobilizations can easily reach 20mg immbolizied protein per ml resin
-Utilizes Sterogene's patented Ultraflow 4 matrix
-cGMP manufacturing; Regulatory Support File available
-DMF with USFDA

Epoxy Activated Ultralfow 4 features epoxy functional groups that react with nucleophilic groups on the ligand. During coupling, the epoxy group is activated by adjusting the pH

Coupling is pH-dependent
-For coupling thiol groups, pH 7-8 (forms a thioether linkage)
-For coupling amino groups, pH 8-10 (forms a stable secondary amine linkage)
-For coupling hydroxyl groups, pH 12 (forms an ether linkage)

This very stable linkage is extremely resistant to hydrolysis.