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PHOTO-MORPHOLINOS Photo-Morpholinos EA 300nmlo $1,061.71  

Photo-Morpholinos incorporate a photo-sensitive subunit cleaved by 365 nm light

Photo-cleavable Morpholinos (Photo-Morpholinos) retain the specificity and efficacy of an unmodified Morpholino oligo but have a photo-sensitive subunit near the middle of the oligo that is cleaved by 365 nm light. The shorter fragments generated from the cleavage have little binding affinity to their target (Fig. 1). Gene Tools will design an optimal Photo-Morpholino for you whether working on translation knockdowns, splice targets, or RNA targets like miRNAs. Photo-Morpholinos give you temporal control of expression, a virtual ON or OFF switch.

Figure 1. Structure of an unmodified Morpholino oligo and a Photo-Morpholino compared